Designed for both research and production.
01
Meets cGMP, ASME, and BPE standards.
03
Supports batch, fed batch, continuous, and perfusion
cultures.
05
Automatic process transfer/feed with SIP/CIP integration.
07
Flat top lid with no welded ports.
02
Suitable for microbial and cell culture processes.
04
Zero dead leg block valves in all transfer/feed lines.
06
Mechanical feeder without valve operations for seamless
nutrient delivery.
08
| SPECIFICATIONS | LABORATORY SCALE FERMENTER | PILOT SCALE FERMENTER | PRODUCTION SCALE FERMENTER |
|---|---|---|---|
| Vessel | Small, compact vessel for lab experiments | Larger than laboratory scale, for process optimization | Industrial-sized for large-volume production |
| Total Volume | 1L to 50L | 50L to 500L | 500L to 20000L and beyond |
| Materials | SS 316L for product contact, SS 304L for non-contact parts | SS 316L for product contact, SS 304L for non-contact parts | SS 316L for product contact, SS 304L for non-contact parts |
| Surface Finish | ≥ 0.4μ mirror finish electro-polished (interior) ≥ 0.2μ matte finish (Exterior) | ≥ 0.4μ mirror finish electro-polished (interior) ≥ 0.2μ matte finish (Exterior) | ≥ 0.4μ mirror finish electro-polished (interior) ≥ 0.2μ matte finish (Exterior) |
| Top/Bottom Driven | Top-driven agitator | Top-driven agitator | Top-driven agitator |
| Sealing Mechanisms | Single or double mechanical seals | Single or double mechanical seals | Single or double mechanical seals |
| Cooling Arrangement | Steam or glycerin cooling system | Steam condensate or glycerin cooling systems | Steam condensate or glycerin cooling systems |
| Safety Interlocks | Basic safety mechanisms | Enhanced safety interlocks for large-scale processes | Advanced safety interlocks integrated into process control |
| Magnetic Coupling | Available for top-driven agitators | Available for top-driven agitators | Available for top-driven agitators |
| Stirrer Types | Rushton, propeller, pitched-blade, BT6, Marine, etc. | Rushton, propeller, pitched-blade, BT6, Marine, etc. | Rushton, propeller, pitched-blade, BT6, Marine, etc. |
| Sampling System | SIP – Sterile Sampling system / Sterile Sampling Collection Unit (On Request) | SIP – Sterile Sampling system / Sterile Sampling Collection Unit (On Request) | SIP – Sterile Sampling system / Sterile Sampling Collection Unit (On Request) |
| Multiple Gas Mixing Station | Two Gas (Air + O2), Four Gas Mixing (Air, N2, O2, CO2) Other Gases (On request) | Two Gas (Air + O2), Four Gas Mixing (Air, N2, O2, CO2) Other Gases (On request) | Two Gas (Air + O2), Four Gas Mixing (Air, N2, O2, CO2) Other Gases (On request) |
| Sparger Options | Standard ring sparger or micro sparger | Multiple sparger options (standard ring, micro sparger, sinter) | High-efficiency sparger systems with customizable pore sizes |
| Sterile Filters | Available in single or double filters (Code 7) | Available in single or double filters (Code 7) | Available in single or double filters (Code 7) |
| Exhaust Line | Exhaust line with condenser, Exhaust heater (On request) | Exhaust line with condenser, Exhaust heater (On request) | Exhaust line with condenser, Exhaust heater |
| Heating Options | Electrical / Steam heating available | Electrical and steam heating options available | Steam heating |
| Closed Loop Jacket Heating | Available in single or double PHE | Uses single or double PHE for efficient heat transfer | Uses single or double PHE for efficient heat transfer |
| Sterilization | FSIP / ESIP | FSIP / ESIP | FSIP / ESIP |
| Automation | Fully automated or semi-automated | Fully automated or semi-automated | Fully automated with high-level control integration |
| Sampling | Manual or automated SIP sampling with sterile containers | Auto or manual SIP sampling with sterile containers | Auto or manual SIP sampling with sterile containers |
| Harvest Arrangement | Manual or automated flush bottom harvest system | Manual or automated flush bottom harvest system | Manual or automated flush bottom harvest system |
| Human Interface | HMI / PC with SCADA interface | HMI / PC with SCADA interface | HMI / PC with SCADA interface |
| Customization | Basic recipe customization options | Supports customizable recipes and advanced features | Full customization for complex recipes and real-time adjustments |
| pH/Redox, DO, CO2, OD | Sensors with single or retractable housing | Sensors with single or retractable housing | Sensors with single or retractable housing |
| Level/Volume | Measured with piezoresistive/Delta P / Load Cell technology | Measured with piezoresistive/Delta P / Load Cell technology | Measured with piezoresistive/Delta P / Load Cell (Upto 2000 L) technology |
| Antifoam | Conductive type with height-adjustable probe | Conductive or pneumatic type with adjustable probe | Advanced foam control with real-time monitoring and adjustment |
| Jenik SCADA | Process monitoring & Control, Complete data Management | Process monitoring & Control, Complete data Management | Process monitoring & Control, Complete data Management |
| Feed System | Peristaltic pump with variable speed control / Sterile cross Value for auto feed | Peristaltic pump with variable speed control / Sterile cross Value for auto feed | Peristaltic pump with variable speed control / Sterile cross Value for auto feed |
| Accessories | Sterile housing, cross valve assembly, flexible hygiene pipes | Auto-sterile housing, valve assembly, flexible transfer pipes | Fully automated sterile transfer, housing, and valve systems |
| Advanced Features | Complete automated / Data management / remote monitoring / Audit trails for cGMP Validation | Complete automated / Data management / remote monitoring / Audit trails for cGMP Validation | Complete automated / Data management / remote monitoring / Audit trails for cGMP Validation |
| QC Documentation | The system complies with all QA/QC requirements, including IQ, OQ, and DQ compliance, validated for GMP practices. | The system complies with all QA/QC requirements, including IQ, OQ, and DQ compliance, validated for GMP practices. | The system complies with all QA/QC requirements, including IQ, OQ, and DQ compliance, validated for GMP practices. |
| Compliance Standard | ASME – BPE 2022 for vessel and piping manufacturing ASME Section VIII (Division 1) for pressure vessel. US FDA 21 CFR 177.2600 for gaskets and O-rings EN/IEC-60204 and UL 508 for electrical work IEC 60529 Standards EU GMP Guide Annex 11 for computerized systems US FDA 21 CFR Part 11 for automation | ASME – BPE 2022 for vessel and piping manufacturing ASME Section VIII (Division 1) for pressure vessel. US FDA 21 CFR 177.2600 for gaskets and O-rings EN/IEC-60204 and UL 508 for electrical work IEC 60529 Standards EU GMP Guide Annex 11 for computerized systems US FDA 21 CFR Part 11 for automation | ASME – BPE 2022 for vessel and piping manufacturing ASME Section VIII (Division 1) for pressure vessel. US FDA 21 CFR 177.2600 for gaskets and O-rings EN/IEC-60204 and UL 508 for electrical work IEC 60529 Standards EU GMP Guide Annex 11 for computerized systems US FDA 21 CFR Part 11 for automation |
